Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.
| Author | |
| Abstract |
:
Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrhythmias in mice with the CPVT1-causative missense mutation Ryr2-R2474S by restoring normal Ca(2+) handling. |
| Year of Publication |
:
2016
|
| Journal |
:
Cardiovascular research
|
| Volume |
:
111
|
| Issue |
:
3
|
| Number of Pages |
:
295-306
|
| Date Published |
:
2016
|
| ISSN Number |
:
0008-6363
|
| URL |
:
https://academic.oup.com/cardiovascres/article-lookup/doi/10.1093/cvr/cvw095
|
| DOI |
:
10.1093/cvr/cvw095
|
| Short Title |
:
Cardiovasc Res
|
| Download citation |
